Autors: Negreva, M., Prodanova, K. S., Vitlianova, K., Madjova, C.
Title: The Intrinsic Coagulation Pathway: Early Activation in Paroxysmal Atrial Fibrillation.
Keywords: atrial fibrillation, coagulation, intrinsic pathway, coagulation factor IX

Abstract: Introduction Coagulation factor IX (FIX) is considered a prothrombotic risk factor. Its increased plasma levels and activity are associated with a significantly increased risk of arterial and/or venous thrombosis. The indicator has been poorly studied in atrial fibrillation (AF).Aim To examine FIX as indicator of coagulation activity in the early hours (up to 24 hours) of the clinical manifestation of paroxysmal atrial fibrillation (PAF).Material and methods 51 non-anticoagulated patients (26 men, 25 women, mean age 59.84±1.60) with PAF and 52 volunteer controls (26 men, 26 women, mean age 59.50±1.46 years) matched in gender, comorbidities, and treatment were selected for the study. FIX plasma coagulation activity was examined using a photometric test.Results All patients were hospitalized between the 2nd and 24th hours after the arrhythmia onset (mean 8.14±0.74 hours). PAF group showed higher FIX activity rel



    East African Scholars J Med Sci., vol. 2, issue 12, pp. 705-711, 2019, Kenya, DOI 10.36349/EASMS.2019.v02i12.008

    Вид: пленарен доклад в международен форум, публикация в издание с импакт фактор, публикация в реферирано издание, индексирана в Web of Science