Autors: Negreva, M., Prodanova, K. S., Zarkova, A.
Title: Paroxysmal atrial fibrillation: an independent risk factor for prothrombotic conditions
Keywords: Paroxysmal atrial fibrillation, Risk factor, Prothrombin fragment 1+2, Fibrinopeptide A, Hypercoagulability.

Abstract: Objective It remains unclear whether atrial fibrillation (AF) alone determines systemic changes in hemocoagulation. Our aim was to examine the prothrombin fragment F1+2 and fibrinopeptide A (FPA) as early markers of coagulation activity still in the first twenty-four hours of paroxysmal AF (PAF) and to correlate them with the arrhythmia onset. Methods 51 non-anticoagulated patients (26 men, 25 women, aged 59.84±1.6 years) and 52 controls (26 men, 26 women, aged 59.50±1.46 years) were sequentially selected. F1+2 and FPA plasma levels were measured by enzyme-linked immunoassays. Results F1+2 was significantly higher in patients (292.61pmol/L±14.03pmol/L vs 183.40pmol/L±8.38pmol/L; p<0.001). FPA was also substantially higher (4.47ng/mL±0.25 ng/mL vs 3.09ng/mL±0.15ng/mL, p<0.001). Among the potential predictors for these deviations: age, gender, BMI, PAF duration and CHA2DS2-VASc score, it was established that higher F1+2 and FPA plasma levels were independently associated only with PAF.

References

    Issue

    JAFIB, vol. 13, issue 2, pp. 1-10, 2020, United States, ISSN 19416911

    Вид: пленарен доклад в международен форум, публикация в издание с импакт фактор, публикация в реферирано издание