| Autors: Negreva, M., Prodanova, K. S., Zarkova, A., Petrov, P. Title: Paroxysmal Atrial Fibrillation: Insight Into the Intimate Mechanisms of Coagulation. Keywords: Atrial fibrillation; Coagulation; Intimate mechanisms. Abstract: Background: Atrial fibrillation (AF) is a hypercoagulable state. However, the intimate mechanisms leading to impaired coagulation and the timing of their activation are unclear. The aim of the study was to investigate the factors that initiate the coagulation cascade in the early hours (up to 48 h) of clinical manifestation of paroxysmal atrial fibrillation (PAF). Methods: Tissue factor (TF) level, coagulation activity of factor VII (FVIIa), factor XII (FXIIa) and factor XI (FXIa) were measured in plasma of 51 non-anticoagulated patients (26 men and 25 women, aged 59.84 ± 11.42 years) and 52 controls (26 men and 26 women, aged 59.50 ± 10.53 years) by enzyme-linked immunoassays and kinetic assays. Results: TF was higher in the PAF group (268.63 ± 90.62 pg/mL vs. 170.21 ± 66.19 pg/mL, P < 0.001) as well as FVIIa (170.82±59.39% vs. 95.17±37.90%, P < 0.001), FXIIa (218.31±84.04% vs. 148.41±53.94%, P < 0.001) and FXIa (178.41±55.94% vs. 111.75±37.33%, P < 0.001). Regression analysis sh References Issue
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Цитирания (Citation/s):
1. Shenglong Yu, Chenxi Li, Huizhuang Guo, Oral anticoagulant therapy for patients with new-onset atrial fibrillation following acute myocardial infarction: A narrative review, Front. Cardiovasc. Med., Sec. Thrombosis, 03 November 2022. https://doi.org/10.3389/fcvm.2022.1046298 ; SJR(2021)=1.44 (Q1) - 2022 - в издания, индексирани в Scopus или Web of Science
2. Serediuk LV, Vakaliuk IP. Клініко-функціональні та психоемоційні закономірності перебігу постійної й пароксизмальної форми фібриляції передсердь. Терапевтика. 2021;2(4):5-16. - 2021 - от чужди автори в чужди издания, неиндексирани в Scopus или Web of Science
Вид: пленарен доклад в международен форум, публикация в реферирано издание, индексирана в Google Scholar
