Autors: Prodanova, K. S.
Title: Optimizing Multiple Drug Administration from Depot by Applying Pharmacokinetic Concepts
Keywords: Compartment modelling, Optimization of multiple drug administration, Individualization of drug therapy

Abstract: For the multiple drug administration from therapeutic reasons it is important to maintain the concentration in the blood plasma in an appropriate range. In the present paper an optimization approach is developed to determine drug dosage regimen to achieve the desired plasma concentrations after application from depot,i.e. oral, muscular, subcutant.The developed methodology allows the optimization of both the dose and the dosage interval. Performance of the developed methodologyis evaluated by computing bias and precision of the estimated trough and peak drugconcentrations that are reached after dosage regimen determinations.This article focuses on an optimal impulsive control of compartment model to individualise dosage regimens of Amikacin in the context of extended dosage intervals.Amikacin is an aminoglycoside antibiotic used to treat various bacterial infections



    INT.J.BIOAUTOMATION, vol. 24, issue 4, pp. 337-348, 2020, Bulgaria, DOI 10.7546/ijba.2020.24.4.000593

    Вид: пленарен доклад в международен форум, публикация в реферирано издание