Autors: Rusev, R. P., Angelov, G. V., Gieva, E. E., Atanasov B., Hristov, M. H.
Title: Microelectronic aspects of hydrogen bond characteristics in active site of beta-lactamase during the acylenzyme reaction
Keywords: Hydrogen bonding networks, acylenzyme reaction, proton trans

Abstract: The behavior of hydrogen bonding networks in active site of beta-lactamase during the acylenzyme reaction cycle is studied. Proton transfer through the HBNs is simulated during the four intermediates of the acylenzyme reaction: free enzyme, Michaelis complex, transient state and acylenzyme. The characteristics of each hydrogen bond are calculated by Markus theory and theory of protein electrostatics. The results showed the similarity of HBN characteristics to characteristics of microelectronic devices such as: double gate MOSFET, current source, and amplifier.



    Annual Journal of Electronics, vol. 6, issue 2, pp. 35-38, 2012, Bulgaria, ISSN 1314-0078

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    Цитирания (Citation/s):
    1. R. P. Rusev, "Transient Analysis of Electronic Circuit Derived from the Active Site β-lactamase Hydrogen Bonding Network", Annual Journal of Electronics, pp.53-56, 2015. ISSN 1314-0078 - 2015 - в български издания
    2. E. E. Gieva, "A microelectronic circuit in CADENCE analogous to michaelis complex of β-lactamase protein," 2017 XXVI International Scientific Conference Electronics (ET), Sozopol, pp. 1-4, 2017. DOI: 10.1109/ET.2017.8124345. - 2017 - в издания, индексирани в Scopus или Web of Science

    Вид: статия в списание, публикация в реферирано издание