Autors: Aleksandrova, M. P., Nikolov, G. T., Mateev, V. M., Tomov, R. T., Iliev, I. C.
Title: Method for Patterning of Conductive Polymers on Flexible Substrates with Possible Applications for Wearable Sensing
Keywords: conductive polymers patterning, flexible substrates, PEDOT:PSS, wearable sensors

Abstract: This study presents a novel fabrication approach for the precise patterning of conductive polymer coatings (graphene/PEDOT:PSS) on flexible substrates. Traditional lithographic methods often result in chemical or thermal degradation of polymer chains, compromising electrical conductivity. The proposed method utilizes an inversely structured gold nanocoating (400–450 nm) as a sacrificial template. By employing a selective lift-off process in a potassium iodide solution, high-resolution polymer topologies are achieved without damaging the active material. The resulting structures exhibit a sheet resistance of 90–100 Ω/sq and maintain linear sensitivity to temperature and humidity, making them suitable for next-generation wearable medical diagnostics.

References

  1. Folorunso O. Olukanmi P. Thokozani S. Conductive polymers’ electronic structure modification for multifunctional applications Mater. Today Commun. 2023 35 106308 10.1016/j.mtcomm.2023.106308
  2. Ates M. A review study of (bio)sensor systems based on conducting polymers Mater. Sci. Eng. C 2013 33 1853 1859 10.1016/j.msec.2013.01.035 23498205
  3. Shahid M.A. Rahman M.M. Hossain M.T. Hossain I. Sheikh M.S. Rahman M.S. Uddin N. Donne S.W. Hoque M.I.U. Advances in Conductive Polymer-Based Flexible Electronics for Multifunctional Applications J. Compos. Sci. 2025 9 42 10.3390/jcs9010042
  4. Bao H.Q. Zin M. Julius D. Leolukman M. Conductive Inks and Conductive Polymeric Coatings U.S. Patent 9,803,097 B2 22 November 2017
  5. Chougle A. Rezk A. Bin Afzal S.U. Mohammed A.K. Shetty D. Nayfeh A. Evolving Role of Conjugated Polymers in Nanoelectronics and Photonics Nano-Micro Lett. 2025 17 230 10.1007/s40820-025-01748-7
  6. Dallaev R. Conductive Polymer Thin Films for Energy Storage and Conversion: Supercapacitors, Batteries, and Solar Cells Polymers 2025 17 2346 10.3390/polym17172346 40942264
  7. He H. Zhang L. Guan X. Cheng H. Liu X. Yu S. Wei J. Ouyang J. Biocompatible Conductive Polymers with High Conductivity and High Stretchability ACS Appl. Mater. Interfaces 2019 11 26185 26193 10.1021/acsami.9b07325 31257845
  8. El-Said W.A. Abdelshakour M. Choi J.-H. Choi J.-W. Application of Conducting Polymer Nanostructures to Electrochemical Biosensors Molecules 2020 25 307 10.3390/molecules25020307 31940924
  9. Le C.V. Yoon H. Advances in the Use of Conducting Polymers for Healthcare Monitoring Int. J. Mol. Sci. 2024 25 1564 10.3390/ijms25031564
  10. Ávila Ramírez A.E. van der Laan D.P. Shah M.B. Wang L. Zeglio E. Savva A. PEDOT:PSS-A Key Material for Bioelectronics Adv. Sci. 2026 13 e13480 10.1002/advs.202513480
  11. Cornuéjols R. Ivanov A. Ghestem A. Albon A. Ytier C. Nordlund M. Mercier J. Bernard C. Rezaei-Mazinani S. Flexible Depth Probes with PEDOT:PSS Microelectrodes for Chronic Recording and Stimulation ACS Appl. Mater. Interfaces 2025 17 42148 42161 10.1021/acsami.5c02872
  12. Liu Z. Liu J. Zhang P. Xu X. PEDOT:PSS as a Bio-Solid Electrolyte Interphase for Neural Interfaces: From Molecular Design to Interfacial Intelligence Polymers 2026 18 20 10.3390/polym18010020
  13. Yan S. Guo Y. Zhang J. Li Y. Shao J. Liu K. PEDOT:PSS in Peripheral Nerve Injury Repair: Electrical Stimulation, Neural Interfaces, and Neural Regenerative Mechanisms Mater. Today Bio 2026 36 102729 10.1016/j.mtbio.2025.102729
  14. Han M. Yildiz E. Kaleli H.N. Karaz S. Eren G.O. Dogru-Yuksel I.B. Senses E. Şahin A. Nizamoglu S. Tissue-Like Optoelectronic Neural Interface Enabled by PEDOT:PSS Hydrogel for Cardiac and Neural Stimulation Adv. Healthc. Mater. 2022 11 e2102160 10.1002/adhm.202102160 34969168
  15. Li J. Mo D. Hu J. Wang S. Gong J. Huang Y. Li Z. Yuan Z. Xu M. PEDOT:PSS-Based Bioelectronics for Brain Monitoring and Modulation Microsyst. Nanoeng. 2025 11 87 10.1038/s41378-025-00948-w
  16. Aleksandrova M. Tomov R. Mateev V. Iliev I. Spray Deposition of Conjugated Polymer/Graphene Ink as an Electrode in Future Chemical Biosensing Devices Proceedings of the 2023 IEEE 33rd International Conference on Microelectronics (MIEL) Nis, Serbia 16–18 October 2023 1 4
  17. Shimura T. Sato S. Tominaga T. Abe S. Yamashita K. Kato T. Ishikuro H. Matsuhisa N. A High-Resolution, Transparent, and Stretchable Polymer Conductor for Wearable Sensor Arrays, A High-Resolution, Transparent, and Stretchable Polymer Conductor for Wearable Sensor Arrays Adv. Mater. Technol. 2023 8 2201992 10.1002/admt.202201992
  18. Tran V.V. Lee S. Lee D. Le T.H. Recent Developments and Implementations of Conductive Polymer-Based Flexible Devices in Sensing Applications Polymers 2022 14 3730 10.3390/polym14183730
  19. Lee S. Ozlu B. Eom T. Martin D.C. Shim B.S. Electrically conducting polymers for bio-interfacing electronics: From neural and cardiac interfaces to bone and artificial tissue biomaterials Biosens. Bioelectron. 2020 170 112620 10.1016/j.bios.2020.112620
  20. Wu S. Sha Z. Wu L. Phan H.-P. He S. Tang J. Xu J. Chu D. Wang C.H. Peng S. Recent Advances in Multimodal Skin-like Wearable Sensors Appl. Phys. Rev. 2024 11 041323 10.1063/5.0217328
  21. Banik R.K. Sia T. Ibrahim M.M. Sivanesan E. Uhelski M. Pena A. Streicher J.M. Simone D.A. Increases in local skin temperature correlate with spontaneous foot lifting and heat hyperalgesia in both incisional inflammatory models of pain Pain Rep. 2023 8 e1097 10.1097/PR9.0000000000001097
  22. Schey B.M. Williams D.Y. Bucknall T. Skin temperature and core-peripheral temperature gradient as markers of hemodynamic status in critically ill patients: A review Heart Lung J. Cardiopulm. Acute Care 2010 39 27 40 10.1016/j.hrtlng.2009.04.002 20109984
  23. Sessler D.I. Skin-temperature gradients are a validated measure of fingertip perfusion Eur. J. Appl. Physiol. 2003 89 401 402 10.1007/s00421-003-0812-8
  24. Carvalho F. Magalhaes C. Fernandez-Llimos F. Mendes J. Gonçalves J. Skin Temperature Response to Thermal Stimulus in Patients with Hyperhidrosis: A Comparative Study J. Therm. Biol. 2022 109 103322 10.1016/j.jtherbio.2022.103322
  25. Wohlrab J. Bechara F.G. Schick C. Naumann M. Hyperhidrosis: A Central Nervous Dysfunction of Sweat Secretion Dermatol. Ther. 2023 13 453 463 10.1007/s13555-022-00885-w
  26. Harwick E. Schwei R.J. Glinert R. Haleem A. Hess J. Keenan T. McBride J.A. Redwood R. Pulia M.S. Comparing Skin Surface Temperature to Clinical Documentation of Skin Warmth in Emergency Department Patients Diagnosed with Cellulitis J. Am. Coll. Emerg. Physicians Open 2022 3 e12712 10.1002/emp2.12712
  27. Ouyang S. Xie Y. Wang D. Zhu D. Xu X. Tan T. Fong H.H. Surface Patterning of PEDOT:PSS by Photolithography for Organic Electronic Devices J. Nanomater. 2015 2015 603148 10.1155/2015/603148
  28. Doshi S. Ludescher D. Karst J. Floess M. Carlström J. Li B. Mintz Hemed N. Duh Y.-S. Melosh N.A. Hentschel M. et al. Direct Electron Beam Patterning of Electro-Optically Active PEDOT:PSS Nanophotonics 2024 13 2271 2280 10.1515/nanoph-2023-0640 38774765
  29. Method for Patterning a Layer of Conductive Polymers 2026 Available online: https://data.epo.org/publication-server/rest/v1.2/patents/EP1054414NWB1/document.pdf (accessed on 20 March 2026)
  30. Kostianovskii V. Sanyoto B. Noh Y.-Y. A Facile Way to Pattern PEDOT:PSS Film as an Electrode for Organic Devices Org. Electron. 2017 44 99 105 10.1016/j.orgel.2017.02.007
  31. Wang Y. Jia S. Zhang Z. PEDOT and PEDOT:PSS Thin-Film Electrodes: Patterning, Modification and Application in Stretchable Organic Optoelectronic Devices J. Mater. Chem. C 2023 11 10435 10454 10.1039/D3TC01579C
  32. Feig V.R. Tran H. Lee M. Liu K. Huang Z. Beker L. Mackanic D.G. Bao Z. An Electrochemical Gelation Method for Patterning Conductive PEDOT:PSS Hydrogels Adv Mater 2019 31 e1902869 10.1002/adma.201902869
  33. Wang W. Liu J. Li H. Zhao Y. Wan R. Wang Q. Xu J. Lu B. Photopatternable PEDOT:PSS Hydrogels for High-Resolution Photolithography Adv. Sci. 2025 12 2414834 10.1002/advs.202414834
  34. Choi J.H. Choi H.J. Shin J.H. Kim H.P. Jang J. Lee H. Enhancement of Organic Solar Cell Efficiency by Patterning the PEDOT:PSS Hole Transport Layer Using Nanoimprint Lithography Org. Electron. 2013 14 3180 3185 10.1016/j.orgel.2013.09.020
  35. Buga C. Viana J.C. Optimization of Print Quality of Inkjet Printed PEDOT:PSS Patterns Flex. Print. Electron. 2022 7 045004 10.1088/2058-8585/ac931e
  36. Plekhanova Y. Tarasov S. Reshetilov A. Use of PEDOT:PSS/Graphene/Nafion Composite in Biosensors Based on Acetic Acid Bacteria Biosensors 2021 11 332 10.3390/bios11090332
  37. Alehosseini M. Kadumudi F.B. Revesz S. Karimi Reikandeh P. Henriksen J.R. Zsurzsan T.-G. Spangenberg J. Dolatshahi-Pirouz A. Self-Maintainable Electronic Materials with Skin-like Characteristics Enabled by Graphene-PEDOT:PSS Fillers Adv. Sci. 2025 12 2410539 10.1002/advs.202410539
  38. Wisitsoraat A. Pakapongpan S. Sriprachuabwong C. Phokharatkul D. Sritongkham P. Lomas T. Tuantranont A. Graphene–PEDOT:PSS on screen printed carbon electrode for enzymatic biosensing J. Electroanal. Chem. 2013 704 208 213 10.1016/j.jelechem.2013.07.012
  39. Gieva E. Ruskova I. Nikolov G. Nikolova B. COMSOL Modelling of Interdigital Capacitive Sensors Proceedings of the 2021 44th International Spring Seminar on Electronics Technology (ISSE) Bautzen, Germany 5–9 May 2021 1 6
  40. Tomov R. Aleksandrova M. Nikolov G. Mateev V. Iliev I. Multifunctional Inkjet-Printed Silver Structures for Wearable Biosensors Proceedings of the 2024 47th International Spring Seminar on Electronics Technology (ISSE) Prague, Czech Republic 15–19 May 2024 Volume 2024 1 4
  41. Aleksandrova M. Mateev V. Iliev I. Behavior of Polymer Electrode PEDOT:PSS/Graphene on Flexible Substrate for Wearable Biosensor at Different Loading Modes Nanomaterials 2024 14 1357 10.3390/nano14161357 39195395

Issue

Micromachines, vol. 17, pp. 467-480, 2026, Switzerland, https://doi.org/10.3390/mi17040467

Вид: статия в списание, публикация в издание с импакт фактор, публикация в реферирано издание, индексирана в Scopus