| Autors: Todorka G. Vladkova., Boris L. Martinov., Anna D. Staneva., Iliana At. Ivanova., Gospodinova, D. N., Madalina G. Albu-Kaya. Title: Preparation and antimicrobial activity of fucoidan containing collagen/(ZnTiO3/SiO2 ) composites. Journal of Chemical Technology and Metallurgy, 58, 654–663. Keywords: collagen/(ZnTiO3 /SiO2 )/fucoidan composites, morphology, an Abstract: The aim of this investigation was to develop collagen based composite biomaterial with improved antimicrobial activity using a combination of antimicrobial agents consisting of zinc titanateembedded in a silane matrix, (ZnTiO3/SiO2) and fucoidan at varied concentrations. The morphology of the investigated porous collagen/(ZnTiO3/SiO2)/fucoidan composites was observed by SEM and their antimicrobial activity was evaluated against four Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Pseudomonas putida, Salmonela holeresius), two Grampositive bacteria (Staphylococcus epidermidis, Bacillus cereus) and two fungi (Candida Lusitania, Saccharomyces cerevisiae) by disk diffusion test. Broad-spectrum antimicrobial activity of the studied porous collagen/(ZnTiO3/SiO2)/fucoidan composites was demonstrated, specific toward the different test microbial strains and dependent on the fucoidan concentration. The specific activity toward different microbial cultures was a References Issue
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