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Autors: Vladkova, T. G., Angelov, O., Stpyanova, D., Gosponova, D. N., Gomes, L., Soares, A., Mergulhao, F., Ivanova, I.
Title: Magnetron co-sputtered TiO2/SiO2/Ag nanocomposite thin coatings inhibiting bacterial adhesion and biofilm formation
Keywords: TiO2/SiO2/Ag nanocomposite coatings; Antimicrobial; Surface characteristics; E. coli growth; Biofilm in urine flow

Abstract: Aim of this study is the development of new functional coatings for medical devices, using magnetron co-sputtering to deposit triple TiO2/SiO2/Ag nanocomposite thin films with expected antimicrobial activity. Some surface characteristics (elemental composition, hydrophilic/hydrophobic balance, surface energy and topography) were estimated to look for correlation with bacterial cells growth and biofilm formation on TiO2/SiO2/Ag coated samples. Strong inhibitory effect toward Escherichia coli growth was found: the number of viable bacterial cells approaches to zero at the first 30 min – 1 h, depending on the Ag content. Biofilm formation in urine flow at 48 h is reduced down to 92% compared to a control glass surface. Direct contact and eluted silver mediated killing were experimentally demonstrated as mechanisms of antibacterial action of the TiO2/SiO2/Ag coatings. These coatings are promising candidate for antimicrobial protection of urinary tract devices for at least 48 h, suggesting


    , vol. 384, 2020, Netherlands, ISSN 0257-8972

    Copyright Elsevier B.V.

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    Вид: статия в списание, публикация в издание с импакт фактор, публикация в реферирано издание, индексирана в Scopus и Web of Science