Autors: Poornima Budime Santhosh., Kamelia Hristova-Panusheva., Lyubomir Stoychev., Natalia Krasteva., Julia Genova., Petrov, T. S.
Title: Femtosecond Laser-Induced Photothermal Effects of Ultrasmall Plasmonic Gold Nanoparticles on the Viability of Human Hepatocellular Carcinoma HepG2 Cells
Keywords: 343 nm fs laser, gold nanoparticles, cancer cells

Abstract: Laser-induced photothermal therapy using gold nanoparticles (AuNPs) has emerged as a promising approach to cancer therapy. However, optimizing various laser parameters is critical for enhancing the photothermal conversion efficacy of plasmonic nanomaterials. In this regard, the present study investigates the photothermal effects of dodecanethiol-stabilized hydrophobic ultrasmall spherical AuNPs (TEM size 2.2 ± 1.1 nm), induced by a 343 nm wavelength ultrafast femtosecond-pulse laser with a low intensity (0.1 W/cm2) for 5 and 10 min, on the cell morphology and viability of human hepatocellular carcinoma (HepG2) cells treated in vitro. The optical microscopy images showed considerable alteration in the overall morphology of the cells treated with AuNPs and irradiated with laser light. Infrared thermometer measurements showed that the temperature of the cell medium treated with AuNPs and exposed to the laser increased steadily from 22 °C to 46 °C and 48.5 °C after 5 and 10 min, respectiv

References

    Issue

    HepG2 Cells. Cells, vol. 13, issue 24, pp. 2139, 2024, United States, PMC, doi: 10.3390/cells13242139

    Вид: публикация в международен форум